Before the events of the series, Coco was an ordinary bandicoot until she was taken from the jungle and genetically enhanced by Doctor Neo Cortex. Coco is first seen in Crash Bandicoot 2: Cortex Strikes Back living on N. Sanity Island with Crash. One day, when the battery for her laptop runs out, she sends Crash off to find a replacement battery for her. When Coco discovers that Crash is gathering Crystals for Cortex, she becomes suspicious of Cortex and decides to hack into Cortex's computer and see what he's really up to. What she finds are detailed schematics for an improved Cortex Vortex and a suspicious-looking space station. She learns of Cortex's real plan just as Crash has gathered all the Crystals, and reveals Cortex's intentions to Crash before he can give the Crystals to Cortex. After Cortex's plan is foiled, Coco is called upon by Aku Aku in Crash Bandicoot 3: Warped to use Doctor Nefarious Tropy's Time-Twisting Machine and gather the powerful Crystals in their original places before Cortex does so. Coco helps by gathering the Crystals in 17th century China, the 18th century Pacific Ocean, and World War I Europe. She is also responsible for the defeat of Cortex's right-hand man Doctor N. Gin on the Moon, with her new pet tiger Pura assisting her.
When the Elementals wreak havoc on the Earth in Crash Bandicoot: The Wrath of Cortex, Coco activates a new Portal Chamber for Crash to use. She helps Crash gather the Power Crystals needed to stop the Elementals by collecting them in a tsunami-ravaged China and an avalanche zone. She also stops an armada of Cortex's space stations from striking Earth. Near the end, she helps Crash and Crunch escape from Cortex's malfunctioning space station. In Crash Twinsanity, Coco is ambushed by Doctor Neo Cortex, who disguises himself as her in order to lure Crash into a trap. Many moments later, Coco believes that Cortex kidnapped Crash, and travels to the Iceberg Lab to confront him. With a swift kick, she attacks Cortex and sends the Power Crystals he was holding flying into the Psychetron. The resulting chain reaction leaves Coco paralyzed until the end of the game.
Coco's inclusion as a playable character in Crash Bandicoot: The Wrath of Cortex was met with a generally lukewarm response among critics. Hilary Goldstein of IGN felt that Coco was a "less powerful" and "less enjoyable" character than Crash and that "she was just not fun the way Crash is". On the subject, Hilary added that "Crash is a silly creature to look at. He's almost absurd, which works great with his various animations. Coco isn't really silly at all. The game isn't called Crash and Coco so why must I be forced to play her? Rather than add variety, Coco detracts from the only real selling point of the game -- Crash Bandicoot."
In Crash of the Titans, Coco is on the verge of creating a device that will be able to recycle butter when she is captured along with Aku Aku by Doctor Neo Cortex. When Nina replaces Cortex, Coco is brainwashed and is forced to finish the Doominator. She ends up completing the Doominator, but is rescued by Crash and is able to stop it at the end of the game. In the Nintendo DS version of the game, she appears as a vendor selling upgrades for Crash's abilities. Coco is a playable character in the cooperation mode of the Wii and Xbox 360 versions of Crash: Mind over Mutant. At the beginning of the game, Coco converts the Doominator's eye into an entertainment system. After seeing an infomercial advertising the "NV", a do-anything personal digital assistant, she receives an NV along with Crunch and quickly becomes addicted. Soon enough, the NV, which Dr. N. Brio filled with negative Mojo, transforms her into a ferocious beast who tries to kill Crash using a giant basketball-launching machine. After being defeated and informed (to her disappointment) that the NV had a negative influence on her, she uses the Doominator's eye to access Cortex's blog and learn what Cortex is planning. She is accessible as the second player's character from that point on.
Coco is a playable character in Crash Team Racing and Crash Bash. The epilogue of Crash Team Racing states that Coco opened up her own Internet dating service after the events of the game. In Crash Bandicoot: The Huge Adventure, Coco builds a device that reverses the effects of Cortex's Planetary Minimizer. In Crash Bandicoot 2: N-Tranced, Coco is abducted by N. Trance and is brainwashed alongside Crunch and Fake Crash. Coco battles Crash in a large battleship inside an active volcano, with Crash attacking the craft while it is reloading its weaponry. Upon snapping out of N. Trance's control, Coco becomes a playable character, gathering two Crystals in space while escaping the wrath of a fireball created by N. Tropy. Coco is a playable character in Crash Nitro Kart as well. In one cutscene, she uses her hacking skills to put the hyperactive Nash to sleep. In Crash Bandicoot Purple: Ripto's Rampage, Coco teams up with the Professor to track down Ripto and Doctor Cortex. Later in the game, they're both kidnapped by Doctor Cortex's niece, Nina Cortex, who keeps them locked up in cages. After being freed from her cage, Coco suggests that Crash and Spyro put a tracer on Cortex and Ripto as to allow the heroes to track the villains back to their hideout. Coco's last major contribution to the story is constructing a portal to Cortex's and Ripto's lair. Coco is a playable character in Crash Tag Team Racing. In the game's story, Coco discovers the sole clue to whoever stole MotorWorld's Power Gems, which is Wumpa Whip. Because of Crash's high consumption of the beverage, she briefly believes (along with the others) that Crash is the culprit, despite the fact that Willie Wumpa Cheeks is the park's lone source of Wumpa Whip. At the end of the game, Coco returns the park's deed to Von Clutch, to whom it belongs. Coco plays a central role in Crash Boom Bang!, in which she is invited by the Viscount to the World Cannonball Race in his search for the Super Big Power Crystal.
Coco's availability as a playable character in Crash: Mind over Mutant was omitted from the PlayStation 2 version of the game due to her distinct animations taking up much of the console's memory. In the PlayStation 2 version, she is replaced by a white-furred version of her brother named "Carbon Crash". Coco is voiced by Vicki Winters in Crash Bandicoot 2: Cortex Strikes Back, by Hynden Walch in Crash Team Racing and by Debi Derryberry from Crash Bandicoot: The Wrath of Cortex onwards. In the Japanese version of the series, she is voiced by Haruna Ikezawa in the PlayStation games, by Ema Kogure in Crash Bandicoot: The Wrath of Cortex, Crash Nitro Kart and Crash Twinsanity, by Satomi Arai in Crash Tag Team Racing and by Risa Tsubaki in Crash Boom Bang!.